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Natural Monophenols as Therapeutics, Antioxidants and Toxins; Electron Transfer, Radicals and Oxidative Stress

[ Vol. 5 , Issue. 3 ]

Author(s):

Peter Kovacic, Ratnasamy Somanathan and Marie-Caline Z. Abadjian   Pages 142 - 151 ( 10 )

Abstract:


Natural monophenols exhibit various properties including antioxidant, therapeutic action and toxicity. This review is unique in application of a unifying mechanistic theme comprising electron transfer, reactive oxygen species and oxidative stress. Representative phenols are as follows: salicylic acid, guaiacol, eugenol, (S)-tyrosine, vanillin, capsaicin, 6-gingerol, carvacrol, thymol, tocopherol, 5-hydroxytryptamine, psilocin, sesamol, estradiol, cannabinoids, etoposide, morphine and heroin, cresols, and other related phenols, such as platensimycin and polyphenols (vancomycin and tetarimycin A). This approach to mode of action may assist in improved drug design.

Keywords:

Antioxidants, electron transfer, monophenols, radicals, therapy, toxicity.

Affiliation:

Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA, USA.



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