Submit Manuscript  

Article Details


Effect of Passion Fruit (Passiflora edulis f. flavicarpa deg.) Peel Flour on the Prognosis of Acute Pancreatitis after Overnutrition During Lactation

[ Vol. 6 , Issue. 3 ]

Author(s):

Glauciane Lacerda-Miranda, Vivian M. Soares, Alessandra A. Thole, Erika Cortez, Lais Carvalho, Carlos E.R. Caetano, Erica P.G. Souza, Anibal S. Moura, Ruy G. Marques, Armando U.O. Sabaa-Srur and Robert E. Smith   Pages 203 - 209 ( 7 )

Abstract:


Background: Acute pancreatitis (AP) is an inflammation process that can affect the systemic inflammatory response syndrome, mainly in obese individuals. The passion fruit peel flour (PFPF) is rich in fibers that help to reduce cholesterol and blood glucose levels.

Methods: In this study, AP was induced by 5% sodium taurocholate inoculation (biliopancreatic duct). The prognosis was evaluated after treatment with PFPF in obese rats overfed during lactation. PFPF (40 mg/kg b.w.) was administered by oral gavage five h after AP induction or sham surgery. Wistar rats were divided into 6 groups: control; sham (CSP), AP (CP) and AP treated with PFPF (40mg) (CP40); obese, sham (OSP), AP (OP), and AP treated with PFPF (40mg) (OP40).

Results: The results demonstrated a significant reduction of blood glucose and triglyceride concentrations after PFPF treatment, compared to AP groups. PFPF treated groups also had lower concentrations of IL-6, and an increased concentration of IL-10 in the OP40 group.

Conclusion: In conclusion, PFPF delays the absorption of simple carbohydrates, due to being rich in pectin (in gel form). This improved glycemic control after AP induction. This may be useful in improving the inflammatory response during acute pancreatitis.

Keywords:

Acute pancreatitis, blood, glucose, glycemic control, inflammatory response, obesity, overnutrition, passion fruit peel flour, triglyceride.

Affiliation:

Park University, 8700 River Park Drive, Parkville, MO 64152 USA.

Graphical Abstract:



Read Full-Text article