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In vitro Characterization of Microspheres Containing Chemically Cross- Linked Gummy Exudates of Cochlospermum religiosum

[ Vol. 9 , Issue. 3 ]

Author(s):

Vipin Kumar Sharma*, Bhaskar Mazumder, Vinod Nautiyal, Prince Prashant Sharma and Yusra Ahmed   Pages 217 - 228 ( 12 )

Abstract:


Background: The polymeric hydrocolloids of natural origin such as gums and mucilages have their own significance in food and pharmaceutical industries due to safety, cost, biodegradability, biocompatibility, etc.

Objective: This study includes the assessment of feasibility of gummy exudates of Cochlospermum religiosum for development of microspheres through emulsification technique.

Methods: The effects of exudates concentration, glutaraldehyde amount and process temperature were analyzed on particle-size and swelling dynamics of developed microspheres. The formulations were also characterized by thermal decomposition and powder X-ray diffraction technique to assess the effect of crosslinking.

Results: The photomicrographs of preparations revealed the formation of microspheres with smooth, spherical and free-flowing nature. The swelling dynamics followed Fick’s diffusion mechanism for swelling media. Fourier transform infrared spectroscopy showed the formation of ether-linkage after crosslinking of exudates by glutaraldehyde. The thermogravimetric curves disclosed the formation of strong bonds during crosslinking.

Conclusion: The ease of gummy exudates of Cochlospermum religiosum for microspheres formation ascribed the potential of these formulations to incorporate therapeutic agent(s) to be applied as novel drug-carriers.

Keywords:

Swelling dynamics, thermogravimetry, powder X-ray diffractometry, crosslinking, gummy exudates, thermal decomposition.

Affiliation:

Department of Pharmaceutical Sciences, Gurukul Kangri Vishwavidyalaya, Haridwar-249404, Uttarakhand, Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-786004, Assam, Department of Pharmaceutical Sciences, Gurukul Kangri Vishwavidyalaya, Haridwar-249404, Uttarakhand, Department of Pharmaceutical Sciences, Gurukul Kangri Vishwavidyalaya, Haridwar-249404, Uttarakhand, Faculty of Pharmacy, Uttarakhand Technical University, Dehradun

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