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In vitro Characterization of Microspheres Containing Chemically Crosslinked Gummy Exudates of Cochlospermum religiosum

Author(s):

Vipin Kumar Sharma*, Bhaskar Mazumder, Vinod Nautiyal, Prince Prashant Sharma and Yusra Ahmed   Pages 1 - 12 ( 12 )

Abstract:


The polymeric hydrocolloids of natural origin such as gums and mucilages have their own significance in food and pharmaceutical industries due to safety, cost, biodegradability, biocompatibility etc. In this study, the gummy exudates of Cochlospermum religiosum was treated with glutaraldehyde through emulsification technique for the development of microspheres. The effects of exudates concentration, glutaraldehyde amount and process temperature were analyzed on particlesize and swelling dynamics. The photomicrographs of preparations revealed the formation of microspheres with smooth, spherical and free-flowing nature. The swelling dynamics followed Fick’s diffusion mechanism for swelling media. Fourier transform infrared spectroscopy showed the formation of ether-linkage after crosslinking of exudates by glutaraldehyde. The thermogravimetric curves disclosed the formation of strong bonds during crosslinking. The ease of gummy exudates of Cochlospermum religiosum for microspheres formation ascribed the potential of these formulations to incorporate therapeutic agent(s) to be applied as novel drug-carriers.

Keywords:

swelling dynamics, thermogravimetry, powder X-ray diffractometry, crosslinking

Affiliation:

Department of Pharmaceutical Sciences, Gurukul Kangri Vishwavidyalaya, Haridwar-249404 Uttarakhand, Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-786004 Assam, Department of Pharmaceutical Sciences, Gurukul Kangri Vishwavidyalaya, Haridwar-249404 Uttarakhand, Department of Pharmaceutical Sciences, Gurukul Kangri Vishwavidyalaya, Haridwar-249404 Uttarakhand, Faculty of Pharmacy, Uttarakhand Technical University, Dehradun



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