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Pharmacological Evaluation of Abietane Diterpenoids from Plectranthus bishopianus as Potent Antibacterial, Antioxidant and Their Cytotoxic Agents

Author(s):

Guvvala Vinodh, Polkam Naveen, Chidambaram Subramanian Venkatesan, Galla Rajitha and Anireddy Jaya Shree*   Pages 1 - 9 ( 9 )

Abstract:


Background: Lamiaceae is one of the large families that occurs worldwide and has species that are adaptable to almost all habitats and altitudes. Plectranthus is an important genus of Lamiaceae, recognized globally as an ornamental as well as a medicinal herb with good economic interest. The Plectranthus species possess antiseptic, vermicidal and purgative activities.

Objective: The isolated compounds (1-3) from Plectranthus bishopianus were tested for their preliminary pharmacological evaluation for antibacterial, antioxidant and cytotoxic activities.

Materials and Methods: The Plectranthus bishopianus leaves were collected from the Western Ghats of India. Extractions followed by isolation of the three compounds and structures were identified by NMR, HRMS.

Results: The isolated compounds, 6,7-dehydroroyleanone (1), 6β-hydroxy-7α-methoxyroyleanone (2) and 6β, 7α-dihyroxyroyleanone (3) showed good antioxidant activity by DPPH method. The results of the cytotoxicity evaluation of the compounds (1-3) displayed excellent activity against MCF-7 cell line with IC50 values at 3.8 μg/mL, 3.85 μg/mL and 3.7 μg/mL respectively, which is more potent than the reference standard cisplatin.

Conclusion: The structures of isolated compounds were confirmed by NMR, LC-HRMS and further pharmacological evaluation was accomplished. In addition, the isolates (1-3) were subjected to insilico molecular properties prediction by employing Molinspiration software for calculating their oral bioavailability and predicted to possess excellent oral bioavailability.

Keywords:

Plectranthus bishopianus, LC-MS; Antioxidant activity, Antibacterial activity, MTT assay, MCF-7 cell line, Molecular properties

Affiliation:

Centre for Chemical Sciences & Technology, Institute of Science & Technology, Jawaharlal Nehru Technological University Hyderabad, Hyderabad-500085, Telangana State, Centre for Chemical Sciences & Technology, Institute of Science & Technology, Jawaharlal Nehru Technological University Hyderabad, Hyderabad-500085, Telangana State, Gland Pharma Ltd, Research and Development, D.P.Pally, Hyderabad-500 043, Telangana State, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women`sUniversity), Tirupati-517502, Andhra Pradesh, Centre for Chemical Sciences & Technology, Institute of Science & Technology, Jawaharlal Nehru Technological University Hyderabad, Hyderabad-500085, Telangana State



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