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Chemo-Diversity of Antibacterial Anthraquinones from the Roots of Morinda morindoides

[ Vol. 9 , Issue. 4 ]

Author(s):

Jean-Luc Aboya Moroh, Yannick Fleury, Adama Coulibaly, Roger Labia and Ivan Leguérinel*   Pages 256 - 261 ( 6 )

Abstract:


Background: Morinda morindoides (Baker) (Rubiaceae) is a medicinal plant with antimicrobial properties currently used in Côte d'Ivoire and other countries. These properties have been described but most of the studies are dealing with crude extracts.

Objective: The chemical structures of the bioactive compounds extracted from Morinda morindoides roots have been characterized.

Methods: The root extracts were analyzed by using HPLC. Fourteen fractions were detected among which 11 compounds have been structurally identified by using a combination of 1H-NMR and 13CNMR and LC-HRMS methodologies.

Results: All these compounds belong to anthraquinone family. The antibacterial activity of the eleven compounds was tested against six strains of microorganisms with ofloxacin as standard (two Gram-negative bacteria, two Gram-positive bacteria and two yeasts). The Minimal Inhibitory Concentrations recorded, varies from 8 to 128 μg / ml. Staphylococcus aureus was the most susceptible organism.

Conclusion: We highlight the chemo-diversity of the antibacterial anthraquinones in the roots of Morinda morindoides.

Keywords:

Morinda morindoides, anthraquinones, antibacterial properties, roots, bioactive compounds, Staphylococcus aureus.

Affiliation:

Laboratoire de Pharmacodynamie Biochimique, Universite de Cocody-Abidjan, 22 BP, 582 Abidjan 22, Universite de Brest, EA 3884, Laboratoire de Biologie et de Chimie Marines, 6 rue de l'Universite, F-29334 Quimper, Laboratoire de Pharmacodynamie Biochimique, Universite de Cocody-Abidjan, 22 BP, 582 Abidjan 22, Universite de Brest, EA3882, Laboratoire Universitaire de Biodiversite et Ecologie Microbienne, UMT14.01 SPORE-RISK, 6 rue de l'Universite, F-29334 Quimper, Universite de Brest, EA3882, Laboratoire Universitaire de Biodiversite et Ecologie Microbienne, UMT14.01 SPORE-RISK, 6 rue de l'Universite, F-29334 Quimper

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