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Chemo-diversity of Antibacterial Anthraquinones from the Roots of Morinda morindoides

Author(s):

Jean-Luc Aboya Moroh, Yannick Fleury, Adama Coulibaly, Roger Labia and Ivan Leguérinel*   Pages 1 - 6 ( 6 )

Abstract:


Morinda morindoides (Baker) (Rubiaceae) is a medicinal plant with antimicrobial properties currently used in Côte d'Ivoire and other countries. These properties have been described but most of the studies are dealing with crude extracts. Consequently, we have characterized the chemical structures of the bioactive compounds extracted from Morinda morindoides roots. The root extracts were analyzed by using HPLC. Fourteen fractions were detected among which 11 compounds have been structurally identified by using a combination of 1H-NMR and 13C-NMR and LC-HRMS methodologies. All these compounds belong to anthraquinone family. The antibacterial activity of the eleven compounds was tested against six strains of microorganisms with ofloxacin as standard (two Gram-negative bacteria, two Gram-positive bacteria and two yeasts). The Minimal Inhibitory Concentrations recorded, varies from 8 to 128 μg / ml. Staphylococcus aureus was the most susceptible organism. We highlight the chemo-diversity of the antibacterial anthraquinones in the roots of Morinda morindoides.

Keywords:

Morinda morindoides, anthraquinones, antibacterial properties, roots.

Affiliation:

Département de Biochimie et Sciences des Aliments, UFR Sciences Biologiques Université Péléforo Gon Coulibaly de Korhogo BP 1328 Korhogo, Université de Brest, EA 3884, Laboratoire de Biologie et de Chimie Marines, 6 rue de l'Université, F-29334 Quimper, Laboratoire de Pharmacodynamie Biochimique, Université de Cocody-Abidjan, 22 BP, 582 Abidjan 22, Université de Brest, EA3882, Laboratoire Universitaire de Biodiversité et Ecologie Microbienne, UMT14.01 SPORE-RISK, 6 rue de l`Université, F-29334 Quimper, Université de Brest, EA3882, Laboratoire Universitaire de Biodiversité et Ecologie Microbienne, UMT14.01 SPORE-RISK, 6 rue de l`Université, F-29334 Quimper



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