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Biological Activities of Carlina oxide Isolated of Carthamus caeruleus Roots

Author(s):

Imane Rihab Mami, Rania Belabbes, Mohammed El Amine Dib*, Boufeldja Tabti, Jean Costa and Alain Muselli  

Abstract:


Background: Carthamus caeruleus roots are traditionally used as healing agents, they help to heal burns and treat skin diseases, they are also used against joint inflammation and are very effective against diseases such as irritable bowel syndrome for cancer patients.

Objectives: This study aimed to chemically characterize i) the essential oil, the hydrosol extract, ii) isolate the major component of both extracts and iii) to evaluate their antioxidant, antifungal and insecticidal activities.

Methods: The chemical composition of the essential oil was analyzed by Gas Chromatography (GC) and Gas Chromatography Mass Spectroscopy (GC/MS). The antioxidant properties were evaluated using two different methods i) Radical scavenging activity (DPPH) and ii) the Ferric-Reducing Antioxidant Power (FRAP), using BHT as positive control. Whereas, the antifungal activity of the essential oil and carlina oxide was investigated against plant fungi. The fumigation Toxicity of C. caeruleus essential oil besides carlina oxide was evaluate against adults of Bactrocera oleae better known as the olive fly.

Results: The essential oil and hydrosol extract were mainly represented by acetylenic compounds such as carline oxide and 13-methoxy carline oxide. carlina oxide was isolated and identified by proton and carbon-13 NMR. The results showed that carlina oxide from roots of C. caeruleus presented interesting antioxidant and antifungal properties, while essential oil has better insecticidal activity. Furthermore, carlina oxide has demonstrated promising in vivo antifungal activity to control infection of apples by Penicillium expansum.

Conclusion: Carlina oxide can be used as a natural food preservative and potential source of sustainable eco-friendly botanical fungicides to protect stored apple against Penicillium expansum.

Keywords:

Carthamus caeruleus, essential oil, hydrosol extract, carlina oxide, biological activities, food preservative

Affiliation:

Laboratoire of Organic Chemistry, Natural Substances and Analyses (COSNA), University of Tlemcen, Laboratoire des Substances Naturelles et Bioactives (LASNABIO), Université de Tlemcen, BP 119, 13000, Laboratoire des Substances Naturelles et Bioactives (LASNABIO), Université de Tlemcen, BP 119, 13000, Laboratoire des Substances Naturelles et Bioactives (LASNABIO), Université de Tlemcen, BP 119, 13000, Laboratoire Chemistry of Natural Products, University of Corsica, CNRS UMR 6134, Campus Grimaldi, BP 52, 20250 Corte, Laboratoire Chemistry of Natural Products, University of Corsica, CNRS UMR 6134, Campus Grimaldi, BP 52, 20250 Corte



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