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Potential Natural Dual Agonist PPARα/γ-induced Antidiabetic and Antidyslipidemic Properties of Safrole-free Nutmeg Seed (Myristica fragrans Houtt) Extract

Author(s):

Keri Lestari*, Ajeng Diantini, Melisa I. Barliana, Tri H. Achmad, Anas Subarnas, Mutakin, Rizky Abdulah, Ronny Lesmana and Jae K. Hwang   Pages 1 - 6 ( 6 )

Abstract:


Background: Nutmeg (Myristica fragrans Houtt) has the potential to control blood glucose and lipid levels. However, it contains safrole compounds, which are dangerous when humans consume them.

Objective: In this study, we eliminated safrole from nutmeg and investigated its antidiabetic and antidyslipidemic properties.

Methods: Nutmeg seeds were powdered, extracted with 90% ethanol, and chromatographed to remove the safrole. Safrole-free nutmeg extract was concentrated, and its antidiabetic and antidyslipidemic agents were tested in a type 2 diabetes mellitus rat model.

Results: The results showed that the blood glucose level decreased by 20% after 2 days of treatment, 30% after 4 days of treatment and 40% after 6 days of treatment with nutmeg extracts. The blood triglyceride level did not change in the first 2 days of treatment, and it decreased by 25% after 4 days of treatment and by another 25% after 6 days of treatment. Luciferase assay showed that safrole- free nutmeg increased the activities of PPAR α and γ in a dose-dependent manner, which marked the potential mechanism of lowering the triglyceride and glucose levels.

Conclusion: Results thus obtained are suggestive of the potential dual effect of safrole-free nutmeg extract on antidiabetic and antidyslipidemic management.

Keywords:

Nutraceutical, nutmeg seed extract, antidiabetic, antidyslipidemic, PPARα/γ

Affiliation:

Department of Pharmacology and Clinical Pharmacy Faculty of Pharmacy, Universitas Padjadjaran. Jl. Raya Bandung Sumedang KM. 21 Jatinangor 45363, Faculty of Pharmacy, Universitas Padjadjaran, Faculty of Pharmacy, Universitas Padjadjaran, Faculty of Medicine Universitas Padjadjaran, Faculty of Pharmacy, Universitas Padjadjaran, Faculty of Pharmacy, Universitas Padjadjaran, Faculty of Pharmacy, Universitas Padjadjaran, Faculty of Medicine Universitas Padjadjaran, Department of Biotechnology & Bioproducts Research Center. Yonsei University



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