Ajay Chowdari M and Giles D* Pages 1 - 5 ( 5 )
Background: Ziziphus jujuba Mill was commonly used for its anti-inflammatory activity in traditional system of medicine.
Objective: The purpose of this study was to examine the isolates of methanolic extract from the fruits of Ziziphus jujuba Mill for its antiulcer, anti-inflammatory, and anticancer activity.
Method: Methanolic extracts of Ziziphus jujuba Mill were subjected to chromatography and eluted using ethyl acetate: methanol mixture and investigated for its structural features using IR, 1H NMR, 13C NMR and mass spectral data. The isolated compound was evaluated for its in vitro COX-2 inhibition studies, cytotoxicity studies, in vivo anti-inflammatory, antiulcer and anticancer activity.
Results: The spectral data revealed that the backbone of the isolate was 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl jujubogenin-20-O-(2,3,4-O-triacetyl)-α-L-rhamnopyranoside. The isolated compound showed significant reduction in inflammation and edema. Moderate anticancer activity was also observed for the isolate.
Conclusion: It was concluded that the isolated saponin possess moderate antiulcer, anti-inflammatory, and anticancer activity which could help in the identification of leads for the treatment of cancer-related inflammation.
Anticancer, Anti-inflammatory, Antiulcer, Saponin, Ziziphus jujuba
Department of Pharmaceutical Chemistry, Acharya & BM Reddy College of Pharmacy, Soldevanahalli, Chikkabanavara Post, Bangalore-560107, Department of Pharmaceutical Chemistry, Acharya & BM Reddy College of Pharmacy, Soldevanahalli, Chikkabanavara Post, Bangalore-560107