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Investigation of Compounds and Biological Activity of Selected Indonesian Marine Sponges

Author(s):

I. Sahidin*, Carla W. Sabandar, Wahyuni, Rini Hamsidi, Sandra Aulia Mardikasari, Wa Ode Sitti Zubaydah, Baru Sadarun, Wa Ode Sitti Musnina, Ahmad Darmawan and Andini Sundowo   Pages 1 - 10 ( 10 )

Abstract:


Marine sponges provided a great source of natural products with promising biological activity. This study was aimed to investigate the chemical constituents of methanol extracts of selected Indonesian marine sponges (Callyspongia sp., Clathria sp., Melophlus sarasinorum, and Xestospongia sp.), collected from the Saponda Islands, Southeast Sulawesi, Indonesia using an LC-MS/MS analysis as well as to evaluate their antimicrobial and antioxidant activities. Chemical screening reported alkaloids, terpenoids, steroids, and saponins from all investigated sponges. The LC-MS/MS analysis identified various compounds which mainly contained steroids. Antimicrobial activity (against Bacillus subtilis, Escherichia coli, Salmonella enterica, and Candida albicans) was only shown by the Xestospongia sp. extract. Meanwhile, extracts of M. sarasinorum, Xestospongia sp., and Callyspongia sp. exhibited potent radical scavenging activity.

Keywords:

Marine sponge, chemical constituents, antimicrobial, antioxidant

Affiliation:

Faculty of Pharmacy, Universitas Halu Oleo, Kendari, Department of Pharmacy, Faculty of Science and Technology, Universitas Sembilanbelas November Kolaka, Kolaka, Faculty of Pharmacy, Universitas Halu Oleo, Kendari, Faculty of Pharmacy, Universitas Halu Oleo, Kendari, Faculty of Pharmacy, Universitas Halu Oleo, Kendari, Faculty of Pharmacy, Universitas Halu Oleo, Kendari, Faculty of Fisheries and Marine Sciences, Universitas Halu Oleo, Kendari, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Tadulako University, Palu, Research Centre for Chemistry, Indonesia Institute of Sciences (LIPI), Kawasan Puspitek, Tangerang Selatan, Banten, Research Centre for Chemistry, Indonesia Institute of Sciences (LIPI), Kawasan Puspitek, Tangerang Selatan, Banten



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