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A Comprehensive Review on Pharmacological Properties of Abrus precatorius L.

Author(s):

Vijay Chopra , Aishwarya Shriwastava, Gopal Khatik, Manish Vyas*, Pramod Yadav, Pradeep Prajapati and Bhupendra Tomar   Pages 1 - 7 ( 7 )

Abstract:


Background: Abrus precatorius L. (A. precatorius) is a valuable plant belongs to family Fabaceae which is a pea family, commonly this plant is known as Gunja or Jequirity, significantly found throughout India mainly Himalaya to Southern India and Ceylon. It is considered a poisonous plant due to the presence of abrin.

Objective: A. precatorius has many pharmacological and biologically active constituents, such as alkaloids, glycosides, and flavonoids in different parts of the plant. The objective of this review is to provide a retrospective study based on its anticancer potential.

Methods: We searched various online database online (Bentham, PubMed, ScienceDirect, ACS, RSC) and scientific publications from the library. The criteria of review were based on A. precatorius, and its application as chemopreventive possessing medicinal value.

Results: Recent studies of A. precatorius are based on the isolation, characterization, and pharmacological evaluation of different secondary metabolites. These constituents possess good cytotoxic properties against various cancer cell lines including breast, lung, liver, ovarian, prostate and leukaemia. A. precatorius is also reported to have anti-diabetic, anti-microbial, abortifacient, antioxidant, anthelmintic activity, antifertility, nephroprotective, and immunomodulatory activities.

Conclusion: Present review summarizes the anticancer potential of Abrus precatorius L. and its constituents. However, extensive research is required to establish it as a potent chemopreventive agent.

Keywords:

Abrus precatorius, abrin, Anticancer, Gunja, Triterpene

Affiliation:

Department of Ayurveda, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, Department of Ayurveda, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, Department of Ayurveda, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, Department of Rasashastra & Bhaishajya Kalpana, All India Institute of Ayurveda, New Delhi, Department of Rasashastra & Bhaishajya Kalpana, All India Institute of Ayurveda, New Delhi, Department of Quality Assurance, Abhilashi College of Pharmacy, Mandi, Himachal Pradesh



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