Submit Manuscript  

Article Details


Chemical Composition and In-Vitro Antimicrobial Screening of Leaf Essential Oil of Plectranthus gerardianus Benth., and Isolation of the Major Constituents of the Oil

[ Vol. 11 , Issue. 5 ]

Author(s):

Navadha Bhatt*, Navabha Joshi, Kapil Ghai and Om Prakash   Pages 690 - 698 ( 9 )

Abstract:


Background: The Lamiaceae (Labiatae) family is one of the most diverse and widespread plant families in terms of ethnomedicine and its medicinal value is based on the concentration of the volatile oil present in it. This family is important for flavor, fragrance and medicinal properties. Many plants belonging to this family have indigenous value.

Method: The essential oil of Plectranthus gerardianusBenth. (Lamiaceae) was analyzed by GC and GC-MS analyses, while the major components were isolated and confirmed by NMR spectroscopy.

Result: The oil was found to be rich in oxygenated monoterpenes, which contribute around 62% of the total oil. The major components identified were fenchone (22.90%) and carvenone oxide (16.75%), besides other mono and sesquiterpenoids. The in-vitro antimicrobial activity of essential oil was tested against three gram-negative bacteria including Pasteurellamultocida, Escherichia coli, and Salmonella enterica, two gram-positive bacteria namely Staphylococcus aureus and Bacillus subtilis and two fungi namely Candida albicans and Aspergillusflavus. The antimicrobial activity of the oil was also compared to the antimicrobial activity of leaf essential oil of another Himalayan plant namely Nepetacoerulescens.

Conclusion: The oil showed in-vitro antimicrobial activity against all the microbial strains and can lessen the ever-growing demand for potentially hazardous antibiotics for treatment.

Keywords:

Plectranthus gerardianus benth.(lamiaceae), antimicrobial activity, pasteurella multicoda, escherichia coli, salmonella enteric, staphylococcus aureus, bacillus subtilis, candida albicans, aspergillus flavus, fenchone, carvenone oxide.

Affiliation:

Department of Chemistry, Graphic Era Hill University, Dehradun, Uttarakhand, Department of Chemistry, Government PG college, GB Pant University of Agriculture and Technology, Ramnagar, Uttarakhand, Department of Chemistry, Graphic Era Hill University, Dehradun, Uttarakhand, Department of Chemistry, GB Pant University of Agriculture and Technology, Ramnagar, Uttarakhand



Read Full-Text article