Sanaz Baghban Rahimi and Ahmad Hosseinzadeh Adli* Pages 598 - 606 ( 9 )
Novel coronavirus (SARS-CoV-2) can infect the respiratory tract and cause severe respiratory syndrome. The excessive inflammatory response is involved in the pathogenicity of the SARS-CoV-2. Symptoms of SARS-CoV-2 are generally associated with immunopathogenesis and may result in pulmonary tissue damage. Melatonin is a natural and multifunctional hormone that is involved in both physiological and pathological conditions in the body, such as immune modulation, anti-inflammation, and antioxidant. Melatonin is found in foods, animal and human milk and increases the expression of anti-inflammatory cytokines and, as an adjuvant treatment in SARS-- CoV-2 infection, it may have considerable therapeutic potential, because of its safety and immunomodulatory effects.
Melatonin, SARS-CoV-2, treatment, anti-inflammatory, immunomodulator, natural.
Department of Microbiology, Golestan University of Medical Sciences, Gorgan, Department of Microbiology, Tabriz University of Medical Sciences, Tabriz, Iran