Yi Ming Shao, Bold Sharavyn, Ping Huang, Hua Naranmandura and Qian Qian Wang* Pages 1 - 7 ( 7 )
Metals occur naturally in soil and many kinds of rocks, particularly in minerals and ores, which also play a vital role in living systems such as plants and animals. Over the large time scale, metal evolution from toxins to drugs has achieved a milestone mean in medicine. Currently, a few metal-based drugs (i.e., metallodrugs) have been used in the clinic to treat patients with different medical conditions, making exciting new developments in anticancer therapeutics (e.g., arsenic trioxide and cisplatin) that quickly move into focus. Moreover, a thorough understanding of the properties and effects of metals on the human body could improve the development and innovation of metal-based drugs. In this review, we have comprehensively described the discovery and development of metal-based anticancer drugs, as well as their side effects in clinical treatment. Although metallodrugs have shown promising outcomes in the treatment of cancers, further investigation is needed to optimize their side effect for broader applications.
Metals, cancer, selenium, platinum, arsenic, antimony, APL.
Inner Mongolia Medical University Pharmacology, Mongolian National University of Medical Sciences Pharmacology, Zhejiang Provincial People’s Hospital Pharmacy, Zhejiang University Hematology, Zhejiang University Hematology